No. There is no evidence that germs adapt or become resistant to PlaneAire® Hands. Alcohol has traditionally been used by healthcare professionals to eliminate germs (microbes). The antimicrobial activity of alcohols is a result of tearing open microbial cell walls and denaturing and coagulating cellular proteins. Since almost all germs are killed immediately and alcohol evaporates immediately, PlaneAire® Hands is highly effective and does not allow germs to develop resistance.