No. Alcohol-based hand sanitizers kill the “bad germs” that you stick to your skin from surfaces that you touch every day. These germs are the superficial skin layer and are easily killed by the alcohol in PlaneAire® Hands . Rest assured, there are minimal changes in the good microbiome which keeps your skin heathy because the good germs live within the deeper layers of the skin and in pores, skin creases, sweat glands, and hair follicles, where an alcohol-based hand sanitizer usually does not penetrate.